Neoepitopes: a new take on beta cell autoimmunity in type 1 diabetesType 1 diabetes is an autoimmune disease caused by T cell-mediated destruction of pancreatic insulin-producing beta cells. The epitopes recognised by pathogenic T cells in human type 1 diabetes are poorly defined; however, a growing body of evidence suggests that T cell responses against neoepitopes contribute to beta cell destruction in type 1 diabetes. Neoepitopes are formed when self-proteins undergo post-translational modification to create a new epitope that is recognised by T- or B cells.
The Evolving Landscape of Autoantigen Discovery and Characterization in Type 1 DiabetesAutoantibodies against insulin, the 65-kDa form of glutamic acid decarboxylase (GAD65), insulinoma-associated protein 2 (IA-2), and zinc transporter 8 (ZnT8) are commonly known as the major specificities in T1D, but their role in the pathophysiology of the disease is not clear.
Pediatric Endocrinology Diabetes and Metabolism However, circulating antibodies in the body of the patient are not the “culprits” for the destruction of insulin-producing cells. The destruction of b cells mainly involves elements of cellular immunity, i.e. macrophages, various T lymphocyte subpopulations, and mediators of the inflammatory response (cytokines, free radicals)
Insulin stained brown above.
Early prediction of autoimmune (type 1) diabetesAutoantibody titres do not always increase closer to the time of diabetes onset. Up to 60% of persons positive for a single autoantibody may revert to seronegativity and patterns of antibody titres may vary without a clear prognostic significance
Environmental factors may trigger either beta cell autoimmunity and the appearance of a first autoantibody or the progression to clinical onset of type 1 diabetes. There is large geographic variation in type 1 diabetes and migrants tend to establish an incidence of diabetes similar to that of the host population (it’s not genetic). Finland (high milk consumption) has the highest national incidence of type 1 diabetes (e.g. a hundredfold that of China) (who are mostly lactose intolerant and have very low milk consumption).
It is thought that cytotoxic T cells, helper T cells, natural killer cells and macrophages contribute to the actual destruction of beta cells [80]. While several modes of action have been proposed in the mouse [81, 82], the pathogenic pathway is less understood in humans’
I don’t like quoting animal experiments for many reasons but in rats “ administration of the pertussis vaccine starting at 8 weeks of life was associated with an increased incidence of diabetes.”The timing of immunization affects the development of diabetes in rodents
In mice ‘Exposure to HiB immunization is associated with an increased risk of IDDM (Type 1 diabetes) Clustering of cases of insulin dependent diabetes (IDDM) occurring three years after hemophilus influenza B (HiB) immunization support causal relationship between immunization and IDDM
In humans; ‘The current findings indicate the there are also clusters of cases of T1DM occurring 2-4 years post-immunization with the pertussis, MMR, and BCG vaccine. Clustering of cases of type 1 diabetes mellitus occurring 2-4 years after vaccination is consistent with clustering after infections
In humans ‘We initiated and funded a collaborative study with Tuomilehto on the effect of the Haemophilus influenzae type b vaccine on type 1 diabetes and found that the data support a causal relation. Furthermore, the potential risk of the vaccine exceeds the potential benefit.’ Association between type 1 diabetes and Hib vaccine
Milk A1 and A2 peptides and diabetes Food-derived peptides, specifically those derived from milk, may adversely affect health by increasing the risk of insulin-dependent diabetes. This position is based on the relationship of type 1 diabetes (T1D) and the consumption of variants A1 and B β-casein from cow's milk. It appears that β-casomorphin-7 (BCM-7) from β-casein may function as an immunosuppressant and impair tolerance to dietary antigens (opioids; also implicated in autism development) in the gut immune system, which, in turn, may contribute to the onset of T1D. There are thirteen genetic variants of β-casein in dairy cattle. Among those variants are A1, A2 (Icelandic cows), and B, which are also found in human milk. The amino acid sequences of β-casomorphins among these bovine variants and those found in human milk are similar, often differing only by a single amino acid. In vitro studies indicate BCM-7 can be produced from A1 and B during typical digestive processes; however, BCM-7 is not a product of A2 digestion (explains medium incidence of type 1 diabetes in Iceland and otherwise linear relationship between increase A1 milk consumption and Type 1 diabetes by country).
This is what I think. There is no evidence that the body is attacking itself.
A healthy microbiome is essential for the body in learning to recognise self and non-self. The bacteria can alter gene expression. Neo-natal use of antibiotics ‘just in case’, regular use of antibiotics, exposure to polysorbate 80 (affects barrier function and is found vaccines and food), vaccines, pesticides and glyphosate (which destroys bacteria by inhibiting the shikimate pathway which produces essential amino acids), prolonged emotional stress, bleach used to make white flour, a diet lacking in fresh fruit and vegetables and a diet high in animal fat will all make the gut leaky and disrupt the microbiome and its protective barrier function’. This allows break down products of bacteria; lipopolysaccharides and proteins; opioids into the blood causing inflammation.
‘Antibodies’ to these cows milk proteins are present in the blood of people these factors apply to. Antibodies do not attack things, they are part of the homeostatic system, high levels associated with any condition are part of the healing and are not causative of the illness. They are found in high tires in the convalescent phase and are bring the body back to balance. Their presence in allegedly 90% of T1D individuals implies that they are attempting to control the inflammation caused by the dysbiosis. ‘Antibodies’ recognise and bind to all new substances that enter the body, perhaps for the body to ‘understand’ them. Their presence does not signify an ‘auto-immune’ disease.
Cows’ milk insulin is very similar to human insulin, and the same antibodies bind to both. When testing the serum from people consuming cows milk; there will naturally be antibodies that bind to human as well as cow’s insulin in it. This does not mean they have ‘autoantibodies’.
The presence of abnormal break down products in the blood and the inflammation they cause explains the detection of T cells. These T cells also recognise the cows’ milk proteins and other peptides and bind to the human equivalents, but they do not kill or attack things. They are, however, involved in creating inflammation to expel the perceived toxins from the body. The response to toxins of the body’s own protective cells does not mean one has an autoimmune disease.
Human beings were not designed to drink milk from another species past weening. The casomorphins in milk soothes and calms the baby and addicts it to suckling. The species specific production of milk and breast feeding has evolved to give maximum survival benefit, not just through nutrition but through the development of the mother and baby bond, over thousands of years. There even seems to be a two way communication, where the contents of the milk is changed by detection of substances in the baby’s saliva.
Prolonged exposure to opioids, if allowed past the protective lining of the gut and brain can affect the developing synaptic connections in the brain as well as the development and functioning of other organs until they may become difficult to reverse, such as the with autism and the insulin producing beta cells.
The biggest risk factors for Parkinsons which is in part due to degeneration of dopaminergic cells, aside from lack of exercise and being repeatedly hit in the head are exposure to pesticides and milk consumption. The biggest exposure to pesticides is through bioaccumulation in milk.
I believe the vaccines will cause toxicity, inflammation and impairments of cell function and metabolism in and of themselves.There is no evidence that the body attacks itself.
I would avoid use of antibiotics unless life or death, avoid vaccines, avoid EMF’s, avoid processed food (which also contains polysorbate 80), pesticides and glyphosate, white flour, probiotics (which seem to slow regrowth of the diversity of bacteria), be aware of emotional stress, practice yoga, avoid animal products and eat a regeneratively grown, organic whole food plant based diet which has been shown to improve sugar control in those who already have Type 1 diabetes.
Jo
I'm going to actually read this post... soon.
Right now, I'm on a quest: Trying to find some ideas for pain management, NATURALLY, for two people I know on SS. I've read, a long time ago, about chewing raw ginger for pain? And a couple of other ideas, such as revolving hot/cold application...
ANYONE? Thanks in advance, and please feel free to direct me to others that might have answers... I'm going to be on Research Mode all day today, and ever more, if needed, FYI. Send me a link, someone's email address, articles or your own ideas, please help if you can.
Thanks for this article I am interested in possible causes for type 1 diabetes, my father aunty and two nephews all got type 1 diabetes at various ages 40, 30, 15, and 18 years of age. Are you aware of JB Classen various published papers implicating HIB, Hep B and MMR Vaccines. Also there was a bleach in wheat whose name escapes me now and not sure if it is still used in wheat, but it used to induce diabetes in rats to study them.
Also this paper and others https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119241/ seem to implicate wheat gluten and there is also a connection between coeliac disease and gluten intolerance. Arthur Firstenberg in The Invisible Rainbow implicates EMF's and radio waves and finally there is the GNM or GKM pathway. Seems to be various "causes" as in most disease hard to pin down to one single thing, like a "virus"